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HIV Treatment Takes Longer to Suppress Higher Viral Loads
IAS 2015 Starting HIV treatment with a higher viral load tends to increase the time it takes to suppress the virus, extending the window of time when an individual may still be infectious. Researchers conducted an analysis of the HPTN 052 study, focusing on 1,036 HIV-positive participants’ data through May 2011, and presented their findings at 8th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention in Vancouver, British Columbia.
The HPTN 052 study of 1,763 mixed-HIV status heterosexual couples ran from April 2005 to May 2015. The study randomly assigned the HIV-positive participants to either start antiretrovirals (ARVs) immediately (the immediate arm), or wait until HIV disease progressed (the delayed arm). In 2011, an interim analysis found that starting ARVs reduced the risk of transmitting the virus by 96 percent. At that time, all participants were offered treatment.
A separate analysis presented at the conference found that none of the HIV-positive partners apparently transmitted the virus to their study partner.
The cumulative probabilities that participants were virally suppressed one, three, six and 12 months into the study were a respective 46.4 percent, 78.5 percent, 89.4 percent and 92.9 percent. The researchers found that having a higher viral load when starting ARVs was linked with a 13 percent increase in the likelihood of taking more time to achieve viral suppression.
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IAS 2015 Starting HIV treatment with a higher viral load tends to increase the time it takes to suppress the virus, extending the window of time when an individual may still be infectious. Researchers conducted an analysis of the HPTN 052 study, focusing on 1,036 HIV-positive participants’ data through May 2011, and presented their findings at 8th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention in Vancouver, British Columbia.
The HPTN 052 study of 1,763 mixed-HIV status heterosexual couples ran from April 2005 to May 2015. The study randomly assigned the HIV-positive participants to either start antiretrovirals (ARVs) immediately (the immediate arm), or wait until HIV disease progressed (the delayed arm). In 2011, an interim analysis found that starting ARVs reduced the risk of transmitting the virus by 96 percent. At that time, all participants were offered treatment.
A separate analysis presented at the conference found that none of the HIV-positive partners apparently transmitted the virus to their study partner.
The cumulative probabilities that participants were virally suppressed one, three, six and 12 months into the study were a respective 46.4 percent, 78.5 percent, 89.4 percent and 92.9 percent. The researchers found that having a higher viral load when starting ARVs was linked with a 13 percent increase in the likelihood of taking more time to achieve viral suppression.
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