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HIV drug PrEP not linked to greater risk for depression in homo or hetero
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A new paper out of the iPrEx study--a randomized, placebo-controlled trial of daily oral HIV pre-exposure prophylaxis (PrEP) in men and transgender women who have sex with men--reported no link between taking Truvada for oral PrEP and experiencing depression as shown in some previous studies.
The current study, published in AIDS and Behavior, systematically examined whether there was a causative link between Truvada and depression. Comparing scores on a depression and a suicidal ideation scale administered during the study, the researchers found there was no difference in depression or suicidality between participants who received Truvada or placebo. There was also no difference in the number of depression-related adverse events between the two study groups. In addition, there was no evidence that PrEP was less efficacious in depressed participants.
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HIV/ AIDS,CANCER MODERN MEDICINES AVAILABLE AT CHEAP RATE.
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A new paper out of the iPrEx study--a randomized, placebo-controlled trial of daily oral HIV pre-exposure prophylaxis (PrEP) in men and transgender women who have sex with men--reported no link between taking Truvada for oral PrEP and experiencing depression as shown in some previous studies.
The current study, published in AIDS and Behavior, systematically examined whether there was a causative link between Truvada and depression. Comparing scores on a depression and a suicidal ideation scale administered during the study, the researchers found there was no difference in depression or suicidality between participants who received Truvada or placebo. There was also no difference in the number of depression-related adverse events between the two study groups. In addition, there was no evidence that PrEP was less efficacious in depressed participants.
However, half of all participants in the iPrEx study, regardless of the study arm they were in, reported depression scores over the threshold for clinically significant depression. It is well documented that rates of depression are substantially higher among gay men and transgender women who have sex with men.
"Depressive symptoms are associated with sexual practices that increase risk for HIV acquisition," said first author Patricia Defechereux, PhD, a senior research associate at the Gladstone Institutes. "The additional protection conferred by PrEP during episodes of depression could avert infections during these especially vulnerable times."
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