TUBERCULOSIS: A NEW DRUG PAMZ WORKS VERY WELL IN DRUG SENSITIVE AND MULTI & EXTREME DRUG RESISTANT TUBERCULOSIS
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TUBERCULOSIS: A NEW DRUG PAMZ WORKS VERY WELL IN DRUG SENSITIVE AND MULTI & EXTREME DRUG RESISTANT TUBERCULOSIS
PROF.DRRAM ,HIV/AIDS,SEX DIS.,SEX WEAK.& ABORTION SPECIALIST
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A once-daily oral regimen known as PaMZ shows promise in both drug-sensitive and multidrug-resistant tuberculosis (TB), new research shows.After 8 weeks of treatment, more patients treated with PaMZ than with the standard TB protocol were culture-negative (71% vs 38%), said Dan Everitt, MD, senior medical officer at the Global Alliance for TB Drug Development.
This could be "a paradigm change for shortening and simplifying drug therapy for drug-sensitive and drug-resistant TB," he said. Drug-resistant patients typically require 5 to 7 drugs given over a 2-year period, with daily injections administered in the first 6 months.
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HIV/ AIDS,CANCER LATEST MEDICINES AVAILABLE AT CHEAP RATE.
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A once-daily oral regimen known as PaMZ shows promise in both drug-sensitive and multidrug-resistant tuberculosis (TB), new research shows.After 8 weeks of treatment, more patients treated with PaMZ than with the standard TB protocol were culture-negative (71% vs 38%), said Dan Everitt, MD, senior medical officer at the Global Alliance for TB Drug Development.
This could be "a paradigm change for shortening and simplifying drug therapy for drug-sensitive and drug-resistant TB," he said. Drug-resistant patients typically require 5 to 7 drugs given over a 2-year period, with daily injections administered in the first 6 months.
It was conducted at 8 sites in South Africa and Tanzania. The primary end point was the rate of change in colony-forming units from sputum on solid culture over an 8-week period.About 20% of the 181 study participants was coinfected with HIV.Drug-sensitive patients were randomized to 1 of 2 PaMZ regimens or the standard TB protocol, consisting of isoniazid, rifampicin, pyrazinamide, and ethambutol.
The PaMZ regimen consisted of moxifloxacin 400 mg and pyrazinamide 1500 mg, plus PA-824 100 mg or PA-824 200 mg.All drug-resistant patients received the 200 mg PaMZ regimen.Investigators found that the PaMZ regimen has active bactericidal activity.
An estimated 2 billion people are infected with TB, and about 1.3 million of these die every year.TB is now also the leading killer of patients with HIV. Drugs can interact with some antiretroviral treatments, so patients with HIV can be problematic.With TB every HIV patient treated with ARV irrespective of CD4 count but first ATT started but HIV IS DELAYED AS IRIS MAY DEVELOP so ARV should be started after 1-2 months of ATT/
The PaMZ regimen consisted of moxifloxacin 400 mg and pyrazinamide 1500 mg, plus PA-824 100 mg or PA-824 200 mg.All drug-resistant patients received the 200 mg PaMZ regimen.Investigators found that the PaMZ regimen has active bactericidal activity.
An estimated 2 billion people are infected with TB, and about 1.3 million of these die every year.TB is now also the leading killer of patients with HIV. Drugs can interact with some antiretroviral treatments, so patients with HIV can be problematic.With TB every HIV patient treated with ARV irrespective of CD4 count but first ATT started but HIV IS DELAYED AS IRIS MAY DEVELOP so ARV should be started after 1-2 months of ATT/
Currently, TB drugs can cost thousands of dollars per treatment course, which is "clearly not doable in poor countries," where TB dominates, Dr. Spigelman pointed out.His organization operates as a not-for-profit product-development partnership that can produce new drugs for considerably less than typical pharmaceutical companies. For example, the cost of a regimen like PaMZ will be about 90% less than it costs today.
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