Two-drug combination more effective to control miscarriage avoiding surgery

Two-drug combination more effective to control miscarriage avoiding surgery

prof .DRRAM,HIV /AIDS,HEPATITIS ,SEX DISEASES & WEAKNESS expert,New Delhi,India, profdrram@gmail.com,+917838059592,+919832025033,ON WHATSAPP

A combination of the drugs mifepristone and misoprostol can help bring closure to some women and their families suffering from miscarriage, and reduces the need for surgical intervention to complete the painful miscarriage process as per study of University of Pennsylvania published in The New England Journal of Medicine.

            Each year in the United States alone approximately 1 million women have miscarriages. When the body does not expel the pregnancy tissue on its own -- the final part of a miscarriage -- women need to undergo a surgical procedure or take the drug misoprostol. Though often preferable for its convenience and privacy -- patients can take it in the comfort of their own homes -- misoprostol does not always work, and many women who use misoprostol are still left with no option but to undergo an invasive procedure they wished to avoid, prolonging an already physically and emotionally difficult situation. For too many women, misoprostol alone just leads to frustration.

           In the new study, 300 women who had been diagnosed with early pregnancy loss -- described as a miscarriage in the first trimester -- were assigned to receive the standard 800 micrograms of misoprostol placed vaginally. Half were also randomly assigned to receive pretreatment with a 200 mg pill of mifepristone, which primes the uterus to respond to misoprostol's contraction-inducing effect.The researchers found that overall, 91.2 percent of women receiving the mifepristone pretreatment plus misoprostol experienced gestational sac expulsion -- the definition of a completed miscarriage -- 83.8 percent by their first follow-up visit, which occurred two days after the treatment on average. Misoprostol alone was only effective 75.8 percent of the time, with 67.1 percent completing by their first follow up visit.

             "High-quality care for women who suffer miscarriage not only improves physical outcomes, but helps alleviate the psychosocial stress that can accompany the loss of a pregnancy," she says. "Given how common miscarriage is and the effectiveness of the drug combination as shown in this new study, any doctor who cares for women who become pregnant, and therefore could have a miscarriage, should be registered to prescribe and dispense mifepristone."