ANTIBIOTIC RESISTANCE GROWING ! A RESISTANT THREATENING BACTERIA FOUND IN US

ANTIBIOTIC RESISTANCE GROWING ! A RESISTANT THREATENING BACTERIA FOUND IN US

DRRAM,HIV /AIDS,HEPATITIS ,SEX DISEASES & WEAKNESS expert,New Delhi,India, profdrram@gmail.com,+917838059592,+919832025033,ON WHATSAPP

Antibiotic resistant is growing day by day and ifnow we donot adapt to use antibiotics carefully a day may come when many bacteria and virus will get resistant to avaiable antibiotics and many super bug as monster will take birth and will be a major threat to humanity.

           Scientists have for the first time isolated an extremely virulent strain of Klebsiella pneumoniae (K pneumoniae) that is resistant to a class of highly effective antibiotic agents and presents a triple threat, from a patient in the US. The previously reported hypervirulent forms were largely antibiotic susceptible. Carbapenem-resistant K. pneumoniae — part of the carbapenem-resistant enterobacteriaceae (CRE) superbug family — is considered an urgent (among top 3) threat by the US Centers for Disease Control and Prevention (CDC).

             “The problem of antibiotic resistance is becoming increasingly alarming. The combination of increased virulence and multidrug resistance makes the situation worse,” said David Weiss, Director at the Emory University in Georgia, US. The results, presented at the annual meeting of ASM Microbe 2018 in Georgia, revealed the K. pneumoniae isolate was heteroresistant to the last resort antibiotic colistin. This means that a small subpopulation of cells showed resistance.

          The researchers are urging more monitoring for this form of bacteria, which have the potential for increased virulence and may be especially worrisome in healthcare settings. For the study, the team examined 265 isolates of carbapenem-resistant K. pneumoniae using a simple “string test”. “The string test is very low-tech. You take a loop, touch it to the bacterial colony, and pull back. The hypermucoviscous one looks like a string of cheese being pulled from a pizza,” said Jessie Wozniak, graduate student at the varsity.

             According to Wozniak, the isolate was approximately ten times more virulent in mice than other isolates of the same sequence type. Further, whole-genome sequencing discovered that the isolate carried several antibiotic resistance genes, along with a new arrangement of virulence genes, but not the same set seen in similar K. pneumoniae isolates from Asian countries, she said.