USE PPI TO REDUCE ACIDITY CAUTIOUSLY AS CAUSE MORE DEATHS

USE PPI TO REDUCE ACIDITY CAUTIOUSLY AS CAUSE MORE DEATHS

Prof Dr,DRAM,HIV /AIDS,HEPATITIS ,SEX DISEASES & WEAKNESS expert,New Delhi,India, +917838059592

    Acidity which is a part of broad term Dysphagia where heartburn,bloating,belching,pain upper abdomen and discomfort are usual symptoms which common people term as gas formation and acidity.It is most commonest gastro intestinal or Abdominal pain disease and usually treated by PROTON PUMP INHIBITORS or PPI as they supress acid formation better than Anataacid,H2 blocker, Anticholinergics, Bismuth or prosta glandins .

          Since their inception ,these are used like a food substance and is available as otc product ,not for acidity but whenever any analgesic given or in heart attack,diabetes,burn,neurosurgery or during anaesthesia of any operation and after any operation Doctors use it with Prokinetcs without any reason with common belief that it will protect stomach and will relief patient.even patient takes it themselves for any upper abdominal discomfort or uneasyness .A cohort study of USA patients published in BMJ revealed that people taking these drugs called as proton pump inhibitors (PPIs) had a 50 percent increased risk of dying over the next five years.                        

          "People have the idea that PPIs are very safe because they are readily available, but there are real risks to taking these drugs, particularly for long periods of time," said Ziyad Al-Aly, Assistant Professor at the Washington University School of Medicine in St. Louis.Further, for every 500 people taking PPIs for a year, there was one extra death that would not have otherwise occurred.Given the millions of people who take PPIs regularly, this could translate into thousands of excess deaths every year, Al-Aly said.

          PPIs have also been linked to a variety of health problems, including serious kidney damage, bone fractures,closteridium difficile infections  and dementia, the researchers said.

          For the study, published in the journal BMJ Open, the researchers examined medical records of some 275,000 users of PPIs and nearly 75,000 people who took another class of drugs – known as H2 blockers – to reduce stomach acid.Both PPIs and H2 blockers are prescribed for serious medical conditions such as upper gastrointestinal tract bleeding, gastroesophageal reflux disease and esophageal cancer.The results revealed a 25 percent increased risk of death in the PPI group compared with the H2 blocker group.

                    This study guides that we should use PPI cautiously when indicated for Duodenal,gastric ulcer,Bleeding or gastritis ,oesphagitis or bratter's disease we must use it for alimited perid of time,use just for sack of use and that too for long period without any strong indication must be prevented and it's sale as OTC product must be stopped.