Urine Of A Patient Can Predict Death Risk-prof drram gi,liver,hiv/aids expert
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Low urine ammonium excretion identifies individuals at high risk of chronic kidney disease progression. Patients with chronic kidney disease who have low levels of ammonium in their urine may be at high risk of the disease progression or death, researchers have warned. Most chronic kidney disease patients in India are obese. A study by US researchers showed that patients with the lowest levels of urine ammonium excretion had a 46 percent higher risk of dying or needing dialysis, and those with intermediate levels had a 14 percent higher risk, irrespective of serum bicarbonate concentration. In addition, those with low ammonium excretion had a 2.6-fold higher risk of developing acidosis, a condition where the body’s fluids contain too much acid — within one year, the researchers said. In order to maintain normal organ function, it is imperative to keep the body’s pH level in balance — measured using the bicarbonate levels in the blood and if it is altered or below 2, chances of death or death risk is increased. “These results suggest that low urine ammonium excretion identifies individuals at high risk of chronic kidney disease progression or death irrespective of the serum bicarbonate concentration,” said researcher from the University of Utah in the US. “Overall, acid levels in the urine provide important information about kidney health above and beyond acid measurements obtained from the blood,” researcher added, in the paper appearing in the Journal of the American Society of Nephrology (JASN). In order to maintain normal organ function, it is imperative to keep the body’s pH level in balance — measured using the bicarbonate levels in the blood. However, this measurement may only partly indicate whether the body is having trouble maintaining its acid-base balance or not because the kidneys are important for eliminating acid in the urine. Thus, the team looked to see if urine levels of ammonium may be a better indicator of acid accumulation in the body. Their analysis included 1,044 individuals with chronic kidney disease.
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