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In First Human Trial, HIV Antibodies Effectively Suppresses HIV Infection
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The antibody, 3BNC117, was tested a year ago in monkeys and recently in 29 human volunteers, showing promise in suppressing HIV.
An antibody designed to fight HIV that generated excitement last year when it was proven to work well in monkeys has now been shown effective in humans.
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The antibody, 3BNC117, was tested a year ago in monkeys and recently in 29 human volunteers, showing promise in suppressing HIV.
An antibody designed to fight HIV that generated excitement last year when it was proven to work well in monkeys has now been shown effective in humans.
The results of a phase 1 clinical trial using antibody 3BNC117 were published today in the journal Nature.In the trial, researchers injected the antibody into 29 volunteers, 17 with HIV and 12 without. The subjects received one intravenous dose of 1, 3, 10, or 30 milligrams of the antibody.
“Among HIV-infected participants, 3BNC117 had the greatest effect on the eight participants who received the highest dose, resulting in significant and rapid decreases in viral load,” the National Institutes of Health (NIH) reported in a news release. “HIV resistance to 3BNC117 was variable, but some individuals remained sensitive … for 28 days.”
The findings are significant because it’s the first time a “new generation” antibody used to fight HIV has been tested in humans. Study authors also hope the investigational antibody may be used to help wipe out latent HIV that hides in an infected person’s body.
Immunotherapy using antibodies has not been particularly successful for HIV up until now. The first round of antibodies tested, known as “first generation” antibodies, did not prove to be broadly neutralizing, meaning that they could not attack multiple strains of HIV.“What’s special about these antibodies is that they have activity against over 80 percent of HIV strains and they are extremely potent,” said Marina Caskey, lead researcher on the new study, in a news release.
The findings are significant because it’s the first time a “new generation” antibody used to fight HIV has been tested in humans. Study authors also hope the investigational antibody may be used to help wipe out latent HIV that hides in an infected person’s body.
Immunotherapy using antibodies has not been particularly successful for HIV up until now. The first round of antibodies tested, known as “first generation” antibodies, did not prove to be broadly neutralizing, meaning that they could not attack multiple strains of HIV.“What’s special about these antibodies is that they have activity against over 80 percent of HIV strains and they are extremely potent,” said Marina Caskey, lead researcher on the new study, in a news release.
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