" IRIS " immune reconstitution inflammatory syndrome,a common reaction seen in HIV patients with infection likeTB /Candida if Haart therapy started never stop haart fearing IRIS during treatment of hiv
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" IRIS " immune reconstitution inflammatory syndrome,a common reaction seen in HIV patients with infection likeTB /Candida if Haart therapy started
PROF.DRRAM ,HIV/AIDS,SEX Diseases,Deaddiction & Hepatitis Expert
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IRIS affects certain HIV-infected individuals whose immune systems are heavily damaged by the virus and who have a treated or undiagnosed AIDS-associated infection and now present with co infection of TB / BACTERIA / FUNGUS as Oppurtunistic Infections.When these individuals start antiretroviral therapy after start of treatment for such oppurtunistic infections,then their immune cells begin to regenerate,the immune system unexpectedly produces an exaggerated response that unmasks or worsens the symptoms of the co-infection and may appear so fatal that often UN EXPERIENCED SPECIALIST want to stop HAART but it is not true HAART should be continued and such reactions as seen in LEPRA REACTION AFTER LEPROSY TREATMENT IS STARTED WITH STEROID,ANTI HISTAMINICS AND SUPPORTIVE THERAPY.IRIS has become a notable challenge in treating HIV disease, particularly in resource-limited settings. The scientists hope that better understanding how and why the syndrome occurs will lead to targeted prevention or therapy.
The analysis showed that the individuals who developed IRIS had a higher proportion of activated T cells before starting antiretroviral therapy compared with those who did not develop IRIS. These activated T cells had the propensity to make a key infection-fighting molecule called interferon gamma both before therapy began and during IRIS episodes, suggesting that the cells may participate in the exaggerated immune response seen during IRIS.
In addition, the surface markers expressed by the T cells -- some with a stimulatory effect and some restraining in nature -- suggested they were highly activated as a result of an encounter with the microbes co-infecting the HIV-infected individuals.
IT IS NOW ESTABLISHED THAT IN TB PATIENT DEVELOPING HIV ,HIV TREATMENT SHOULD BE STARTED WITH IN 21 DAYS IF CD4 OR T LYMPHOCYTE IS LESS AND SHOULD BE CONTINUED EVEN IF IRIS DEVELOPS AS MORE PRODUCTION OF GOOD IMMUNE CELLS HELP BETTER LONGIVITY TO PATIENT THAN WHO START HIV TREATMENT LATER BUT IF CD4 OR T LYMPHOCYTES MORE THEN HAART CAN BE STARTED WITHIN 2-3 MONTHS OF THERAPY OF TB OR CANDIDA INFECTION AS IRIS IS AVOIDED BUT HAART NEVER DELAYED FOR 4-6 MONTHS OR AFTER COMPLETION OF TB THERAPY AS IT LEADS MORE DEATH AND COMPLICATIONS.
profdrram@gmail.com,+917838059592,+919832025033,DELHI,INDIA
HIV/ AIDS,CANCER MODERN MEDICINES AVAILABLE AT CHEAP RATE.
FOLLOW ON FACE BOOK:www.facebook.com/ramkumar
FOLLOW ON TWITTER:www.twitter.com/profdrram
IRIS affects certain HIV-infected individuals whose immune systems are heavily damaged by the virus and who have a treated or undiagnosed AIDS-associated infection and now present with co infection of TB / BACTERIA / FUNGUS as Oppurtunistic Infections.When these individuals start antiretroviral therapy after start of treatment for such oppurtunistic infections,then their immune cells begin to regenerate,the immune system unexpectedly produces an exaggerated response that unmasks or worsens the symptoms of the co-infection and may appear so fatal that often UN EXPERIENCED SPECIALIST want to stop HAART but it is not true HAART should be continued and such reactions as seen in LEPRA REACTION AFTER LEPROSY TREATMENT IS STARTED WITH STEROID,ANTI HISTAMINICS AND SUPPORTIVE THERAPY.IRIS has become a notable challenge in treating HIV disease, particularly in resource-limited settings. The scientists hope that better understanding how and why the syndrome occurs will lead to targeted prevention or therapy.
The analysis showed that the individuals who developed IRIS had a higher proportion of activated T cells before starting antiretroviral therapy compared with those who did not develop IRIS. These activated T cells had the propensity to make a key infection-fighting molecule called interferon gamma both before therapy began and during IRIS episodes, suggesting that the cells may participate in the exaggerated immune response seen during IRIS.
In addition, the surface markers expressed by the T cells -- some with a stimulatory effect and some restraining in nature -- suggested they were highly activated as a result of an encounter with the microbes co-infecting the HIV-infected individuals.
IT IS NOW ESTABLISHED THAT IN TB PATIENT DEVELOPING HIV ,HIV TREATMENT SHOULD BE STARTED WITH IN 21 DAYS IF CD4 OR T LYMPHOCYTE IS LESS AND SHOULD BE CONTINUED EVEN IF IRIS DEVELOPS AS MORE PRODUCTION OF GOOD IMMUNE CELLS HELP BETTER LONGIVITY TO PATIENT THAN WHO START HIV TREATMENT LATER BUT IF CD4 OR T LYMPHOCYTES MORE THEN HAART CAN BE STARTED WITHIN 2-3 MONTHS OF THERAPY OF TB OR CANDIDA INFECTION AS IRIS IS AVOIDED BUT HAART NEVER DELAYED FOR 4-6 MONTHS OR AFTER COMPLETION OF TB THERAPY AS IT LEADS MORE DEATH AND COMPLICATIONS.
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