TWO DIARRHOEAL DISEASES: IBS & IBD : BETTER DIAGNOSTIC TESTS
DR.D.R.NAKIPURIA ,SENIOR GASTRO INTEST SPECIALIST & HIV/AIDS CONSULTANT drnakipuria@gmail.com, 09434143550,07838059592,+919832025033.,
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IBD(INFLAMMATORY BOWEL DISEASE OR CROHN'S DISEASE / ULCERATIVE COLITIS etc are chronic disease involving large Gut where patient present with severe diarrhoea with blood and pus over months hard to control by anerobic antibiotics and anti amoebics )& IND (IRRITABLE BOWEL SYNDROME, dirrhoea with alternation bouts of constipations painn abdome over months hard to control by simple antiddiarrhoeal medicines) are often of great concern for Doctors and patients as until definite diagnosis is made ,patient suffer from these disese for very long time in years and diagnosis is very challenging as by routine COLONOSCOPY AND BIOPSY OFEN A DIAGNOSIS DOES NOT COME,BRIUM ENEMA,USG etc are hardly helpful ,Recently ANCA AND ASCA antibodies determination in BLOOD and Faecl protectin level help slightly for dignosis ,As no diagnosis made then INFLAMMATORY NEEDS long Antiinflammatory drus like Meslzine,SUlpha salazine with Calcium blockers,Steroid,Immunosuppressant like Immurn while Irritable nneds more antispasmodic with stool binders diet and medicines like Raccecadotril and pre and proantibiotics.
Until Diagnosis is made treatment is almost symptomatic Scientists have for the first time developed a blood test to determine if a person is suffering from Irritable Bowel Syndrome (IBS), or another serious condition such as Inflammatory Bowel Disease (IBD).Researchers have conclusively identified a test for antibodies that form against a particular protein, vinculin, found in the guts of patients, many of whom suffered acute gastroenteritis at some point.
"This is a major breakthrough. It is the first test with a high specificity for IBS, likely based on a pathological mechanism of the disease," said Cedars-Sinai physician researcher Mark Pimentel, co-author of the study.In the study, 221 patients were evaluated; some had a diagnosis of IBS, some were diagnosed with IBD and some were healthy, with no symptoms.Anti-vinculin antibodies were significantly elevated in IBS patients as compared to those with IBD or those who were healthy.
The research was presented at the American College of Gastroenterology's 78th Annual Scientific Meeting in San Diego.
DR.D.R.NAKIPURIA ,SENIOR GASTRO INTEST SPECIALIST & HIV/AIDS CONSULTANT drnakipuria@gmail.com, 09434143550,07838059592,+919832025033.,
FOLLOW ON FACE BOOK:www.facebook.com/drnakipuria
FOLLOW ON TWITTER:www.twitter.com/dr.d.r.nakipuria
IBD(INFLAMMATORY BOWEL DISEASE OR CROHN'S DISEASE / ULCERATIVE COLITIS etc are chronic disease involving large Gut where patient present with severe diarrhoea with blood and pus over months hard to control by anerobic antibiotics and anti amoebics )& IND (IRRITABLE BOWEL SYNDROME, dirrhoea with alternation bouts of constipations painn abdome over months hard to control by simple antiddiarrhoeal medicines) are often of great concern for Doctors and patients as until definite diagnosis is made ,patient suffer from these disese for very long time in years and diagnosis is very challenging as by routine COLONOSCOPY AND BIOPSY OFEN A DIAGNOSIS DOES NOT COME,BRIUM ENEMA,USG etc are hardly helpful ,Recently ANCA AND ASCA antibodies determination in BLOOD and Faecl protectin level help slightly for dignosis ,As no diagnosis made then INFLAMMATORY NEEDS long Antiinflammatory drus like Meslzine,SUlpha salazine with Calcium blockers,Steroid,Immunosuppressant like Immurn while Irritable nneds more antispasmodic with stool binders diet and medicines like Raccecadotril and pre and proantibiotics.
Until Diagnosis is made treatment is almost symptomatic Scientists have for the first time developed a blood test to determine if a person is suffering from Irritable Bowel Syndrome (IBS), or another serious condition such as Inflammatory Bowel Disease (IBD).Researchers have conclusively identified a test for antibodies that form against a particular protein, vinculin, found in the guts of patients, many of whom suffered acute gastroenteritis at some point.
"This is a major breakthrough. It is the first test with a high specificity for IBS, likely based on a pathological mechanism of the disease," said Cedars-Sinai physician researcher Mark Pimentel, co-author of the study.In the study, 221 patients were evaluated; some had a diagnosis of IBS, some were diagnosed with IBD and some were healthy, with no symptoms.Anti-vinculin antibodies were significantly elevated in IBS patients as compared to those with IBD or those who were healthy.
The research was presented at the American College of Gastroenterology's 78th Annual Scientific Meeting in San Diego.
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